Fast Synaptic Subcortical Control of Hippocampal Circuits

被引：202

作者：

Varga, Viktor ^{[1
]}

Losonczy, Attila ^{[2
]}

Zemelman, Boris V. ^{[2
]}

Borhegyi, Zsolt ^{[1
]}

Nyiri, Gabor ^{[1
]}

Domonkos, Andor ^{[1
]}

Hangya, Balazs ^{[1
]}

Holderith, Noemi ^{[1
]}

Magee, Jeffrey C. ^{[2
]}

Freund, Tamas F. ^{[1
]}

机构：

[1] Inst Expt Med, H-1083 Budapest, Hungary

[2] Howard Hughes Med Inst, Ashburn, VA 20147 USA

来源：

SCIENCE | 2009年 / 326卷 / 5951期

基金：

匈牙利科学研究基金会;

关键词：

RAPHE NEURONS; MODULATION; DIVERSITY; RESPONSES; CONTAIN; RHYTHM;

D O I：

10.1126/science.1178307

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cortical information processing is under state-dependent control of subcortical neuromodulatory systems. Although this modulatory effect is thought to be mediated mainly by slow nonsynaptic metabotropic receptors, other mechanisms, such as direct synaptic transmission, are possible. Yet, it is currently unknown if any such form of subcortical control exists. Here, we present direct evidence of a strong, spatiotemporally precise excitatory input from an ascending neuromodulatory center. Selective stimulation of serotonergic median raphe neurons produced a rapid activation of hippocampal interneurons. At the network level, this subcortical drive was manifested as a pattern of effective disynaptic GABAergic inhibition that spread throughout the circuit. This form of subcortical network regulation should be incorporated into current concepts of normal and pathological cortical function.

引用

页码：449 / 453

页数：5

共 21 条

[1] Driving fast-spiking cells induces gamma rhythm and controls sensory responses [J].