Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms

被引:32
作者
da Silva, Vanessa Cavalcante
da Costa Ramos, Flavio Jose
Freitas, Elizabete Malaquias
de Brito-Marques, Paulo Roberto
de Holanda Cavalcanti, Marcia Nery
D'Almeida, Vania
Cabral-Filho, Jose Eulalio
Cartaxo Muniz, Maria Tereza
机构
[1] Univ Fed Pernambuco, Inst Ciencias Biol, BR-50100130 Recife, PE, Brazil
[2] Univ Fed Pernambuco, Fac Ciencias Med, Unidad Neurol Comportamento, Dept Neurol, BR-50100130 Recife, PE, Brazil
[3] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil
[4] Inst Materno Infantil Pernambuco, Recife, PE, Brazil
关键词
homocysteine; MTHFR; Alzheimer's disease;
D O I
10.1590/S0004-282X2006000600010
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Objective: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. Method: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total plasma homocysteine (Hcy) levels were determined by HPLC and genotyping for MTHFR by PCR/RFLP. Mann-Whitney "U" test was used to compare quantitative variable, Fisher-Freeman-Halton test to compare genotypes and allele proportions and Chi-square test to other qualitative variables. Results: AD patients presented higher total plasma Hcy levels than controls and the difference was statistically significant. No differences in the C677T and A1298C MTHFR polymorphisms distributions were found between patients and controls. Plasma homocysteine concentration did not change with MTHFR genotypes. Conclusion: Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil.
引用
收藏
页码:941 / 945
页数:5
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