Circulating tumour-derived nucleic acids in cancer patients: potential applications as tumour markers

被引：51

作者：

Chan, K. C. A.

Lo, Y. M. D.

机构：

[1] Chinese Univ Hong Kong, Dept Chem Pathol, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, State Key Lab Oncol S China, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 05期

关键词：

tumour marker; plasma/serum DNA; plasma/serum RNA; circulating nucleic acids;

D O I：

10.1038/sj.bjc.6603625

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour-associated changes have been observed in the circulating nucleic acids of cancer patients and have been proposed to be useful for the detection and monitoring of cancers. In this review, different approaches for detecting tumour-associated nucleic acids in the circulation and their potential applications as tumour markers are discussed.

引用

页码：681 / 685

页数：5

共 29 条

[1] Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis.: Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study
Bazan, V.
Bruno, L.
Augello, C.
Agnese, V.
Calo, V.
Corsale, S.
Gargano, G.
Terrasi, M.
Schiro, V.
Di Fede, G.
Adamo, V.
Intrivici, C.
Crosta, A.
Rinaldi, G.
Latteri, F.
Dardanoni, G.
Grassi, N.
Valerio, M. R.
Colucci, G.
Macaluso, M.
Russo, A.
[J]. ANNALS OF ONCOLOGY, 2006, 17 : VII84 - VII90
[2] Chan ATC, 2002, JNCI-J NATL CANCER I, V94, P1614, DOI 10.1093/jnci/94.21.1614
[3] Investigation into the origin and tumoral mass correlation of plasma Epstein-Barr virus DNA in nasopharyngeal carcinoma
Chan, KCA
Chan, ATC
Leung, SF
Pang, JCS
Wang, AYM
Tong, JHM
To, KF
Chan, LYS
Tam, LLS
Chung, NYF
Zhang, J
Lo, KW
Huang, DP
Lo, YMD
[J]. CLINICAL CHEMISTRY, 2005, 51 (11) : 2192 - 2195
[4] Effects of preanalytical factors on the molecular size of cell-free DNA in blood
Chan, KCA
Yeung, SW
Lui, WB
Rainer, TH
Lo, YMD
[J]. CLINICAL CHEMISTRY, 2005, 51 (04) : 781 - 784
[5] Size distributions of maternal and fetal DNA in maternal plasma
Chan, KCA
Zhang, J
Hui, ABY
Wong, N
Lau, TK
Leung, TN
Lo, KW
Huang, DWS
Lo, YMD
[J]. CLINICAL CHEMISTRY, 2004, 50 (01) : 88 - 92
[6] Chan KCA, 2003, CANCER RES, V63, P2028
[7] Chen XQ, 1996, NAT MED, V2, P1033
[8] MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis
Ding, CM
Chiu, RWK
Lau, TK
Leung, TN
Chan, LC
Chan, AYY
Charoenkwan, P
Ng, ISL
Law, HY
Ma, ESK
Xu, XM
Wanapirak, C
Sanguansermsri, T
Liao, C
Ai, MATJ
Chui, DHK
Cantor, CR
Lo, YMD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) : 10762 - 10767
[9] The detection of oesophageal adenocarcinoma by serum microsatellite analysis
Eisenberger, C. F.
Stoecklein, N. H.
Jazra, S.
Hosch, S. B.
Peiper, M.
Scheunemann, P.
Esch, J. Schulte am
Knoefel, W. T.
[J]. EJSO, 2006, 32 (09): : 954 - 960
[10] Circulating deoxyribonucleic acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy
Gautschi, O
Bigosch, C
Huegli, B
Jermann, M
Marx, A
Chassé, E
Ratschiller, D
Weder, W
Joerger, M
Betticher, DC
Stahel, RA
Ziegler, A
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (20) : 4157 - 4164

← 1 2 3 →