Fatal bupropion overdose

被引：51

作者：

Harris, CR ^{[1
]}

Gualtieri, J ^{[1
]}

Stark, G ^{[1
]}

机构：

[1] MINNESOTA REG POISON CTR,BLOOMINGTON,MN

来源：

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 1997年 / 35卷 / 03期

关键词：

D O I：

10.3109/15563659709001220

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Background: Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence. Case Report: We report a case of a 26-year-old man who ingested 23 g bupropion, developed seizures and hypoxia, and presented in cardiac arrest. The patient was resuscitated in the emergency department, but died 4 d after supportive intensive care. Conclusions: Bupropion overdose may lead to recurrent seizures, hypoxia and death. Aggressive management of severe bupropion overdose is recommended.

引用

页码：321 / 324

页数：4

共 10 条

[1] DRUG-INDUCED AND NUTRITION-INDUCED HYPOPHOSPHATEMIA - MECHANISMS AND RELEVANCE IN THE CRITICALLY ILL [J].