Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix

被引：35

作者：

Delvenne, Philippe ^{[1
]}

Herman, Ludivine ^{[1
]}

Kholod, Natalia ^{[1
]}

Caberg, Jean-Hubert ^{[1
]}

Herfs, Michae ^{[1
]}

Boniver, Jacques ^{[1
]}

Jacobs, Nathalie ^{[1
]}

Hubert, Pascale ^{[1
]}

机构：

[1] Univ Liege, CHU Sart Tilman, Dept Pathol, CRCE,CBIG, B-4000 Liege, Belgium

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2007年 / 264卷 / 1-2期

关键词：

sexual hormones; human papillomavirus; metaplasia; carcinogenesis;

D O I：

10.1016/j.mce.2006.10.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

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