Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

被引:298
作者
Meier, PJ
Eckhardt, U
Schroeder, A
Hagenbuch, B
Stieger, B
机构
[1] Div. Clin. Pharmacol. and Toxicol., Department of Medicine, University Hospital
[2] Div. Clin. Pharmacol. and Toxicol., Dept. of Medicine, University of Zurich
关键词
D O I
10.1002/hep.510260641
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.
引用
收藏
页码:1667 / 1677
页数:11
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