Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver

被引：298

作者：

Meier, PJ

Eckhardt, U

Schroeder, A

Hagenbuch, B

Stieger, B

机构：

[1] Div. Clin. Pharmacol. and Toxicol., Department of Medicine, University Hospital

[2] Div. Clin. Pharmacol. and Toxicol., Dept. of Medicine, University of Zurich

来源：

HEPATOLOGY | 1997年 / 26卷 / 06期

关键词：

D O I：

10.1002/hep.510260641

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes Their properties indicate that an overall hepatic clearance of albumin-bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.

引用

收藏

页码：1667 / 1677

页数：11

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