Syntheses around the transglycosylation step in peptidoglycan biosynthesis

被引：60

作者：

Welzel, P ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 12期

关键词：

D O I：

10.1021/cr040634e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The transglycosylases involved in peptidoglycan biosynthesis are promising targets for new anti-infectives. The enzyme is located on the cell surface, thus making it easily accessible to small molecular drugs. These drugs that target the transglycosylation step may therefore be less prone to resistance development. New antibiotics include teicoplanin, ramoplanin, nisin, moenomycins, coleophomones, and mannopeptimycins. The syntheses of lipid II, the monomeric precursor of peptidoglycan are also discussed in detail.

引用

页码：4610 / 4660

页数：51

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