Fluoroquinolone enhances the mutation frequency for meropenem-selected carbapenem resistance in Pseudomonas aeruginosa, but use of the high-potency drug doripenem inhibits mutant formation

被引：66

作者：

Tanimoto, Koichi ^{[2
]}

Tomita, Haruyoshi ^{[1
]}

Fujimoto, Shuhei ^{[1
]}

Okuzumi, Katsuko ^{[3
]}

Ike, Yasuyoshi ^{[1
,2
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Bacteriol, Gunma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Lab Bacteria Drug Resistance, Gunma 3718511, Japan

[3] Dokkyo Med Univ Hosp, Dept Safety Med, Adm Div Infect Control, Shimotsuga, Tochigi 3210293, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 10期

关键词：

D O I：

10.1128/AAC.00464-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mutation frequency for carbapenem resistance in Pseudomonas aeruginosa strains that were selected with carbapenems was enhanced in the presence of subinhibitory concentrations of fluoroquinolones. The mutants showed either a loss of OprD activity or increased mexAB-oprM expression. The highest mutant isolation frequency was obtained by selection with meropenem, while doripenem inhibited mutant growth.

引用

页码：3795 / 3800

页数：6

共 33 条

[21] Metallo-β-lactamase-producing gram-negative bacilli:: Laboratory-based surveillance in cooperation with 13 clinical laboratories in the Kinki region of Japan [J].

Nishio, H ;

Komatsu, M ;

Shibata, N ;

Shimakawa, K ;

Sueyoshi, N ;

Ura, T ;

Satoh, K ;

Toyokawa, M ;

Nakamura, T ;

Wada, Y ;

Orita, T ;

Kofuku, T ;

Yamasaki, K ;

Sakamoto, M ;

Kinoshita, S ;

Aihara, M ;

Arakawa, Y .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (11) :5256-5263

[22]

OZAKI S, 2007, REPORT RES PROJECT B

[23] Carbapenem resistance mechanisms in Pseudomonas aeruginosa clinical isolates [J].

Pai, H ;

Kim, JW ;

Kim, J ;

Lee, JH ;

Choe, KW ;

Gotoh, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (02) :480-484

[24] EMERGENCE OF RESISTANCE TO IMIPENEM DURING THERAPY FOR PSEUDOMONAS-AERUGINOSA INFECTIONS [J].

QUINN, JP ;

DUDEK, EJ ;

DIVINCENZO, CA ;

LUCKS, DA ;

LERNER, SA .

JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (02) :289-294

[25]

SAKYO S, 1997, 37 INT C ANT AG CHEM, P183

[26] Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa -: The high potency of a new carbapenem doripenem [J].

Sakyo, Shihomi ;

Tomita, Haruyoshi ;

Tanimoto, Koichi ;

Fujimoto, Shuhei ;

Ike, Yasuyoshi .

JOURNAL OF ANTIBIOTICS, 2006, 59 (04) :220-228

[27]

SHIMOJIMA M, 2007, MED CONSULT NEW REME, V43, P697

[28] SUPERINFECTIONS BY ESCHERICHIA-COLI RESISTANT TO FLUOROQUINOLONES IN IMMUNOCOMPROMISED PATIENTS [J].

SOMOLINOS, N ;

ARRANZ, R ;

DELREY, MC ;

JIMENEZ, ML .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1992, 30 (05) :730-731

[29] PROPERTIES OF PENICILLIN-BINDING PROTEINS OF ESCHERICHIA-COLI K-12 [J].

SPRATT, BG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 72 (02) :341-352

[30] ORAL ENOXACIN FOR INFECTION PREVENTION IN ADULTS WITH ACUTE NONLYMPHOCYTIC LEUKEMIA [J].

TALBOT, GH ;

CASSILETH, PA ;

PARADISO, L ;

CORREACORONAS, R ;

BOND, L ;

RAZA, A ;

PREISLER, H ;

VOGLER, WR ;

GOLDBERG, J ;

WIERNIK, P ;

GULCALP, R ;

MAZZA, J ;

KAHN, SB ;

HINES, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (03) :474-482

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