Multisensory Signaling Shapes Vestibulo-Motor Circuit Specificity

被引:55
作者
Basaldella, Emanuela [1 ,2 ]
Takeoka, Aya [1 ,2 ]
Sigrist, Markus [1 ,2 ]
Arber, Silvia [1 ,2 ]
机构
[1] Univ Basel, Dept Cell Biol, Biozentrum, CH-4056 Basel, Switzerland
[2] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
基金
瑞士国家科学基金会;
关键词
SPINAL-CORD; MUSCLE-SPINDLE; ALPHA-MOTONEURONES; SYNAPTIC CONNECTIVITY; PARTITION CELLS; SENSORY NEURONS; CRITICAL PERIOD; CAT; NUCLEUS; MOUSE;
D O I
10.1016/j.cell.2015.09.023
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
The ability to continuously adjust posture and balance is necessary for reliable motor behavior. Vestibular and proprioceptive systems influence postural adjustments during movement by signaling functionally complementary sensory information. Using viral tracing and mouse genetics, we reveal two patterns of synaptic specificity between brainstem vestibular neurons and spinal motor neurons, established through distinct mechanisms. First, vestibular input targets preferentially extensor over flexor motor pools, a pattern established by developmental refinement in part controlled by vestibular signaling. Second, vestibular input targets slow-twitch over fast motor neuron subtypes within extensor pools, while proprioceptors exhibit inversely correlated connectivity profiles. Genetic manipulations affecting the functionality of proprioceptive feedback circuits lead to adjustments in vestibular input to motor neuron subtypes counterbalancing the imposed changes, without changing the sparse vestibular input to flexor pools. Thus, two sensory signaling systems interact to establish complementary synaptic input patterns to the final site of motor output processing.
引用
收藏
页码:301 / 312
页数:12
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