Monitoring immune responses in cancer patients receiving tumor vaccines

被引：26

作者：

Walker, EB

Disis, MLN

机构：

[1] Robert W Franz Canc Res Ctr, Earle A Chiles Res Inst, Providence Portland Med Ctr, Portland, OR 97213 USA

[2] Univ Washington, Dept Med Oncol, Seattle, WA 98195 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2003年 / 22卷 / 3-4期

关键词：

immunomonitoring assays; cancer vaccines;

D O I：

10.1080/08830180305226

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical evaluation of therapeutic tumor vaccines has resulted in examination and comparison of the types of immune function assays required to monitor tumor antigen-stimulated T cell effector function in immunized patients. Three of the most commonly used assays include ELISPOT, tetramer assay, and cytokine flow cytometry (CFC). Discussed are the method and principles for each assay and an assessment of important methodological, reagent, and data acquisition issues that are relevant for the accurate and effective use of the assays. The sensitivity and utility of the assays and present arguments advocating their integrated use in future immunomonitoring studies are also discussed.

引用

收藏

页码：283 / 319

页数：37

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