Glucocorticoids in T cell apoptosis and function

被引:298
作者
Herold, MJ [1 ]
McPherson, KG [1 ]
Reichardt, HM [1 ]
机构
[1] Univ Wurzburg, Inst Virol & Immunobiol, D-97078 Wurzburg, Germany
关键词
apoptosis; glucocorticoid; T cell development; caspase; Bcl-2; family; transgenesis; gene targeting;
D O I
10.1007/s00018-005-5390-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucocorticoids (GCs) are a class of steroid hormones which regulate a variety of essential biological functions. The profound anti-inflammatory and immunosuppressive activity of synthetic GCs, combined with their power to induce lymphocyte apoptosis place them among the most commonly prescribed drugs worldwide. Endogenous GCs also exert a wide range of immunomodulatory activities, including the control of T cell homeostasis. Most, if not all of these effects are mediated through the glucocorticoid receptor, a member of the nuclear receptor superfamily. However, the signaling pathways and their cell type specificity remain poorly defined. In this review, we summarize our present knowledge on GC action, the mechanisms employed to induce apoptosis and the currently discussed models of how they may participate in thymocyte development. Although our knowledge in this field has substantially increased during recent years, we are still far from a comprehensive picture of the role that GCs play in T lymphocytes.
引用
收藏
页码:60 / 72
页数:13
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