Targeting a Monocyte Subset to Reduce Inflammation

被引：29

作者：

Gordon, Siamon ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

CIRCULATION RESEARCH | 2012年 / 110卷 / 12期

关键词：

DENDRITIC CELLS; MACROPHAGES; MICE;

D O I：

10.1161/RES.0b013e31825ec26d

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recently in Nature Biotechnology, Leuschner et al(1) described an elegant method of limiting the recruitment of a proinflammatory subset of monocytes in mouse models of inflammation. Although providing prospects for therapeutic application, especially in cardiovascular diseases, it raises questions that make it necessary to proceed with caution.

引用

页码：1546 / 1548

页数：3

共 11 条

[1]

Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas [J].

Cheong, Cheolho ;

Matos, Ines ;

Choi, Jae-Hoon ;

Dandamudi, Durga Bhavani ;

Shrestha, Elina ;

Longhi, M. Paula ;

Jeffrey, Kate L. ;

Anthony, Robert M. ;

Kluger, Courtney ;

Nchinda, Godwin ;

Koh, Hyein ;

Rodriguez, Anthony ;

Idoyaga, Juliana ;

Pack, Maggi ;

Velinzon, Klara ;

Park, Chae Gyu ;

Steinman, Ralph M. .

CELL, 2010, 143 (03) :416-429

[2]

Development of Monocytes, Macrophages, and Dendritic Cells [J].

Geissmann, Frederic ;

Manz, Markus G. ;

Jung, Steffen ;

Sieweke, Michael H. ;

Merad, Miriam ;

Ley, Klaus .

SCIENCE, 2010, 327 (5966) :656-661

[3]

TRANSFER OF DIABETES IN MICE PREVENTED BY BLOCKADE OF ADHESION-PROMOTING RECEPTOR ON MACROPHAGES [J].

HUTCHINGS, P ;

ROSEN, H ;

OREILLY, L ;

SIMPSON, E ;

GORDON, S ;

COOKE, A .

NATURE, 1990, 348 (6302) :639-641

[4]

Comparison of gene expression profiles between human and mouse monocyte subsets [J].

Ingersoll, Molly A. ;

Spanbroek, Rainer ;

Lottaz, Claudio ;

Gautier, Emmanuel L. ;

Frankenberger, Marion ;

Hoffmann, Reinhard ;

Lang, Roland ;

Haniffa, Muzlifah ;

Collin, Matthew ;

Tacke, Frank ;

Habenicht, Andreas J. R. ;

Ziegler-Heitbrock, Loems ;

Randolph, Gwendalyn J. .

BLOOD, 2010, 115 (03) :E10-E19

[5]

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis [J].

Leuschner, Florian ;

Rauch, Philipp J. ;

Ueno, Takuya ;

Gorbatov, Rostic ;

Marinelli, Brett ;

Lee, Won Woo ;

Dutta, Partha ;

Wei, Ying ;

Robbins, Clinton ;

Iwamoto, Yoshiko ;

Sena, Brena ;

Chudnovskiy, Aleksey ;

Panizzi, Peter ;

Keliher, Edmund ;

Higgins, John M. ;

Libby, Peter ;

Moskowitz, Michael A. ;

Pittet, Mikael J. ;

Swirski, Filip K. ;

Weissleder, Ralph ;

Nahrendorf, Matthias .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (01) :123-137

[6]

Therapeutic siRNA silencing in inflammatory monocytes in mice [J].

Leuschner, Florian ;

Dutta, Partha ;

Gorbatov, Rostic ;

Novobrantseva, Tatiana I. ;

Donahoe, Jessica S. ;

Courties, Gabriel ;

Lee, Kang Mi ;

Kim, James I. ;

Markmann, James F. ;

Marinelli, Brett ;

Panizzi, Peter ;

Lee, Won Woo ;

Iwamoto, Yoshiko ;

Milstein, Stuart ;

Epstein-Barash, Hila ;

Cantley, William ;

Wong, Jamie ;

Cortez-Retamozo, Virna ;

Newton, Andita ;

Love, Kevin ;

Libby, Peter ;

Pittet, Mikael J. ;

Swirski, Filip K. ;

Koteliansky, Victor ;

Langer, Robert ;

Weissleder, Ralph ;

Anderson, Daniel G. ;

Nahrendorf, Matthias .

NATURE BIOTECHNOLOGY, 2011, 29 (11) :1005-U73

[7]

Alternative Activation of Macrophages: An Immunologic Functional Perspective [J].

Martinez, Fernando O. ;

Helming, Laura ;

Gordon, Siamon .

ANNUAL REVIEW OF IMMUNOLOGY, 2009, 27 :451-483

[8]

Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon [J].

Rivollier, Aymeric ;

He, Jianping ;

Kole, Abhisake ;

Valatas, Vassilis ;

Kelsall, Brian L. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (01) :139-155

[9]

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells [J].

Schulz, Christian ;

Perdiguero, Elisa Gomez ;

Chorro, Laurent ;

Szabo-Rogers, Heather ;

Cagnard, Nicolas ;

Kierdorf, Katrin ;

Prinz, Marco ;

Wu, Bishan ;

Jacobsen, Sten Eirik W. ;

Pollard, Jeffrey W. ;

Frampton, Jon ;

Liu, Karen J. ;

Geissmann, Frederic .

SCIENCE, 2012, 336 (6077) :86-90

[10]

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites [J].

Swirski, Filip K. ;

Nahrendorf, Matthias ;

Etzrodt, Martin ;

Wildgruber, Moritz ;

Cortez-Retamozo, Virna ;

Panizzi, Peter ;

Figueiredo, Jose-Luiz ;

Kohler, Rainer H. ;

Chudnovskiy, Aleksey ;

Waterman, Peter ;

Aikawa, Elena ;

Mempel, Thorsten R. ;

Libby, Peter ;

Weissleder, Ralph ;

Pittet, Mikael J. .

SCIENCE, 2009, 325 (5940) :612-616

← 1 2 →