A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

被引：1929

作者：

Schulz, Christian ^{[1
,2
]}

Perdiguero, Elisa Gomez ^{[1
,2
]}

Chorro, Laurent ^{[1
,2
]}

Szabo-Rogers, Heather ^{[3
]}

Cagnard, Nicolas ^{[4
]}

Kierdorf, Katrin ^{[5
,6
]}

Prinz, Marco ^{[5
,6
]}

Wu, Bishan ^{[7
]}

Jacobsen, Sten Eirik W. ^{[7
]}

Pollard, Jeffrey W. ^{[8
]}

Frampton, Jon ^{[9
]}

Liu, Karen J. ^{[3
]}

Geissmann, Frederic ^{[1
,2
]}

机构：

[1] Kings Coll London, CMCBI, London SE1 1UL, England

[2] Kings Coll London, Peter Gorer Dept Immunobiol, London SE1 9RT, England

[3] Kings Coll London, Dept Craniofacial Dev, London SE1 9RT, England

[4] Univ Paris 05, Plateforme Bioinformat, INSERM IRNEM IFR94, F-75015 Paris, France

[5] Univ Freiburg, Dept Neuropathol, D-79106 Freiburg, Germany

[6] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79106 Freiburg, Germany

[7] Univ Oxford, Haematopoiet Stem Cell Biol Lab, Weatherall Inst Mol Med, John Radcliffe Hosp, Oxford OX3 9DS, England

[8] Albert Einstein Coll Med, Dept Dev & Mol Biol, Ctr Study Reprod Biol & Womens Hlth, New York, NY 10461 USA

[9] Univ Birmingham, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England

来源：

SCIENCE | 2012年 / 336卷 / 6077期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金; 欧洲研究理事会;

关键词：

MONONUCLEAR PHAGOCYTE SYSTEM; IMMUNOHISTOCHEMICAL LOCALIZATION; SELF-RENEWAL; AORTIC ENDOTHELIUM; LANGERHANS CELLS; MICROGLIA DERIVE; FLT3; EXPRESSION; ANTIGEN F4/80; YOLK-SAC; MACROPHAGES;

D O I：

10.1126/science.1219179

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive HSCs. We thus reinvestigated macrophage development. We found that the transcription factor Myb was required for development of HSCs and all CD11b(high) monocytes and macrophages, but was dispensable for yolk sac (YS) macrophages and for the development of YS-derived F4/80(bright) macrophages in several tissues, such as liver Kupffer cells, epidermal Langerhans cells, and microglia-cell populations that all can persist in adult mice independently of HSCs. These results define a lineage of tissue macrophages that derive from the YS and are genetically distinct from HSC progeny.

引用

页码：86 / 90

页数：5

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