p8 upregulation sensitizes astrocytes to oxidative stress

被引：23

作者：

Carracedo, A ^{[1
]}

Egia, A ^{[1
]}

Guzmán, M ^{[1
]}

Velasco, G ^{[1
]}

机构：

[1] Univ Complutense, Sch Biol, Dept Biochem & Mol Biol 1, Madrid 28040, Spain

来源：

FEBS LETTERS | 2006年 / 580卷 / 06期

关键词：

astrocytes; DNA arrays; p8; oxidative stress; heme oxygenase 1; p38; MAPK;

D O I：

10.1016/j.febslet.2006.01.084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we studied the mechanism of cell sensitization to oxidative stress by analyzing the gene expression profile of serum-deprived astrocytes. Exposure to serum-free medium (i) sensitized astrocytes to oxidative stress, (ii) reduced the expression of several genes involved in protection against oxidative stress, including heme oxygenase 1, and (iii) changed the expression of several genes involved in the control of cell survival, including the stress-regulated protein p8. Our results support that serum deprivation sensitizes astrocytes to oxidative stress via a p38 mitogen-activated protein kinase-dependent p8 upregulation that leads in turn to decreased heme oxygenase 1 expression. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1571 / 1575

页数：5

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