Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase

被引:22
作者
Wu, JJ
Afar, DEH
Phan, H
Witte, ON
Lam, KS
机构
[1] Univ Calif Davis, US Davis Danc Ctr, Dept Internal Med, Div Hematol Oncol, Sacramento, CA 95817 USA
[2] Univ Calif Los Angeles, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
关键词
D O I
10.2174/1386207023330516
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Using a combinatorial peptide library that is based on the one-bead one-peptide approach we identified 14 peptide substrates for the c-ABL protein tyrosine kinase, which define three distinct consensus sequence groups. This is distinct from many serine/threonine kinases, which often phosphorylate only one major consensus sequence. The three consensus sequences accurately predict phosphorylation sites in cellular ABL substrates proven to play a role in cell signaling. Our data suggest that protein tyrosine kinases have evolved to recognize multiple substrate motifs.
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页码:83 / 91
页数:9
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