Effect of Lipoxin A4 on Myocardial Ischemia Reperfusion Injury Following Cardiac Arrest in a Rabbit Model

被引：27

作者：

Chen, Zhiqiao ^{[1
,2
]}

Wu, Zhe ^{[3
]}

Huang, Congxin ^{[4
]}

Zhao, Yan ^{[2
]}

Zhou, Yirong ^{[3
]}

Zhou, Xianlong ^{[3
]}

Lu, Xingxing ^{[3
]}

Mao, Lele ^{[3
]}

Li, Siying ^{[3
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Wuhan 430060, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Emergency Ctr, Wuhan 430071, Peoples R China

[3] Wuhan Univ, Coll Med, Wuhan 430071, Peoples R China

[4] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China

来源：

INFLAMMATION | 2013年 / 36卷 / 02期

关键词：

cardiac arrest (CA); cardiopulmonary resuscitation (CPR); ischemia-reperfusion injury (IRI); inflammation; lipoxin A4; TRIGGERED 15-EPI-LIPOXIN A(4); NF-KAPPA-B; INFLAMMATION; DYSFUNCTION; EXPRESSION; APOPTOSIS; CYTOKINES; PROTECTS; RECEPTOR; ANALOG;

D O I：

10.1007/s10753-012-9567-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the present study, we investigated the effect of lipoxin A4 on myocardial ischemia-reperfusion injury (IRI) following cardiac arrest (CA) in a rabbit model. Lipoxin A4 is a metabolite of arachidonic acid in the eicosanoid, it is called "brake signal" for its anti-inflammatory activity. Some inflammatory factors (IL-1 beta, IL-6, TNF-alpha, and IL-10), NF-kappa B p65, infarct ratios, apoptotic index, cardiac troponin I (cTnI), hemodynamic and myocardial structures were measured or observed in different groups. Lipoxin A4 inhibits the expression of IL-1 beta, IL-6, and TNF-alpha, the values of the infarct ratios, apoptotic index, the level of serum cTnI and NF-kappa B p65. Meanwhile, it improves the expression of IL-10, hemodynamic, myocardial structure, and function. These indicate that lipoxin A4 mitigates postresuscitation myocardial IRI in which anti-inflammation and suppression of NF-kappa B activation may play an important role.

引用

页码：468 / 475

页数：8

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