Role of HMGB1 in cardiovascular diseases

被引：108

作者：

Li, W

Sama, AE

Wang, HC

机构：

[1] NYU, Sch Med, N Shore Univ Hosp, Dept Emergency Med, Manhasset, NY 11030 USA

[2] Feinstein Inst Med Res, Ctr Immunol & Inflammat, Manhasset, NY 11030 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2006年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.coph.2005.10.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A nuclear protein, high mobility group box 1 (HMGB1), is released passively by necrotic cells, and actively by macrophages/monocytes in response to exogenous and endogenous inflammatory stimuli. After binding to the receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4), HMGB1 activates vascular endothelial cells and macrophages/monocytes to express proinflammatory cytokines, chemokines and adhesion molecules. Pharmacological suppression of its activities or release is protective against lethal endotoxemia and sepsis, establishing HMGB1 as a critical mediator of lethal systemic inflammation. In light of the pathogenic role of inflammation in cardiovascular diseases, we propose that HMGB1, a proinflammatory cytokine derived from both injured endothelium and activated macrophages/monocytes, could contribute to the progression of atherosclerosis and other cardiovascular diseases.

引用

页码：130 / 135

页数：6

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