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Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease

被引：303
作者：
Lue, HQ
Kleemann, R
Calandra, T
Roger, T
Bernhagen, J
机构：
[1] Univ Stuttgart, Inst Interfacial Engn, Biochem Lab, D-70569 Stuttgart, Germany
[2] TNO, PG, Gaubius Lab, NL-2301 CE Leiden, Netherlands
[3] CHU Vaudois, Div Infect Dis, CH-1011 Lausanne, Switzerland
来源：
MICROBES AND INFECTION | 2002年 / 4卷 / 04期
关键词：
cytokine; MIF; inflammation; septic shock; signaling; JAB1;
D O I：
10.1016/S1286-4579(02)01560-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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页码：449 / 460
页数：12
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