Solid phase synthesis of a ψ[CH2NH] pseudopeptide by ligation of a peptidyl aldehyde with a resin-bound amino peptide

被引：5

作者：

Gros, C ^{[1
]}

Galéotti, N ^{[1
]}

Pascal, R ^{[1
]}

Jouin, P ^{[1
]}

机构：

[1] Ctr CNRS INSERM, Lab CNRS Mecanismes Mol Commun Cellulaires, F-34094 Montpellier 5, France

来源：

TETRAHEDRON | 1999年 / 55卷 / 40期

关键词：

peptide analogues/mimetics; aldehydes; solid-phase synthesis;

D O I：

10.1016/S0040-4020(99)00689-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Solid phase synthesis of psi[CH2NH] pseudopeptide 3 was accomplished by reductive amination of peptidyl aldehyde 1 with resin bound amino peptide 2. No epimerization took place during the aldehyde preparation or the reductive amination step. This convergent strategy should facilitate the synthesis of analogues of the neuropeptide PACAP. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：11833 / 11842

页数：10

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