Synthesis of peptidyl aldehydes from thiazolidines

被引：14

作者：

Galeotti, N

Plagnes, E

Jouin, P

机构：

[1] Lab. CNRS Mecanismes Moleculaires C., 34094 Montpellier Cedex 5

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 14期

关键词：

INTERLEUKIN-1-BETA CONVERTING-ENZYME; LEUPEPTIN ANALOGS; ORGANIC SYNTHESIS; 2-THIAZOLINES; DERIVATIVES; INHIBITORS; OXAZOLINES; POTENT; SERINE;

D O I：

10.1016/S0040-4039(97)00383-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptidyl aldehydes were synthesized using thiazolidine peptides as precursors. Hydrolysis of the heterocycles is easily accomplished using cupper salts to furnish the peptidyl aldehydes with very good yield and with no epimerization. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：2459 / 2462

页数：4

共 21 条

[1]

ALTMAN LJ, 1971, TETRAHEDRON LETT, V49, P4709

[2] SYNTHESIS OF A POTENT, REVERSIBLE INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME [J].