SYNTHESIS OF A POTENT, REVERSIBLE INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME

被引：77

作者：

CHAPMAN, KT

机构：

[1] Department of Medicinal Chemical Research Merck Research Laboratories Rahway

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81209-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient synthesis of L - 709,049, a potent inhibitor of Interleukin-1-beta converting enzyme (ICE) is reported. The aspartic acid aldehyde moiety is protected as the corresponding O-benzylacylal which can be conveniently coupled to AcTyrValAla and hydrogenolyzed to afford the desired product.

引用

页码：613 / 618

页数：6

共 14 条

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