Endothelial Progenitor Cells: Implications for Cardiovascular Disease

被引：53

作者：

Moebius-Winkler, Sven ^{[1
]}

Hoellriegel, Robert ^{[1
]}

Schuler, Gerhard ^{[1
]}

Adams, Volker ^{[1
]}

机构：

[1] Univ Leipzig, Heart Ctr Leipzig, Dept Internal Med & Cardiol, D-04289 Leipzig, Germany

来源：

CYTOMETRY PART A | 2009年 / 75A卷 / 01期

关键词：

endothelial progenitor cells; cardiovascular disease; review; BONE-MARROW-CELLS; ACUTE MYOCARDIAL-INFARCTION; HEMATOPOIETIC STEM-CELLS; CORONARY-ARTERY-DISEASE; IMPROVES CARDIAC-FUNCTION; COLONY-STIMULATING FACTOR; NITRIC-OXIDE-SYNTHASE; GROWTH-FACTOR; GENE-TRANSFER; ACCELERATE REENDOTHELIALIZATION;

D O I：

10.1002/cyto.a.20669

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial progenitor cells (EPCs) reside in the bone marrow and are mobilized into the circulation by specific stimuli such as certain drugs, ischemia, and exercise training. Once in the circulation EPCs are thought to participate in the maintenance of the endothelial cell layer. Recently it was clearly demonstrated that the amount and function of EPCs is significantly impaired in different cardiovascular diseases. Furthermore, the level of circulating EPCs predicts the occurrence of cardiovascular events and death from cardiovascular causes and may help to identify patients at increased cardiovascular risk. After demonstrating the beneficial effect of applied EPCs in several animal experiments, these cells were also used to treat humans with different cardiovascular diseases. This review will focus on the characterization and liberation of EPCs from the bone marrow, as well as on the most important clinical cardiovascular diseases for which EPCs were used therapeutically. (C) 2008 International Society for Advancement of Cytometry

引用

页码：25 / 37

页数：13

共 131 条

[91] Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells -: In vivo neovascularization induced by stromal-derived factor-1α [J].

Salcedo, R ;

Wasserman, K ;

Young, HA ;

Grimm, MC ;

Howard, OMZ ;

Anver, MR ;

Kleinman, HK ;

Murphy, WJ ;

Oppenheim, JJ .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (04) :1125-1135

[92] Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes -: Results of 3 randomized studies [J].

Sandri, M ;

Adams, V ;

Gielen, S ;

Linke, A ;

Lenk, K ;

Kränkel, N ;

Lenz, D ;

Erbs, S ;

Scheinert, D ;

Mohr, FW ;

Schuler, G ;

Hambrecht, R .

CIRCULATION, 2005, 111 (25) :3391-3399

[93] Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure [J].

Sarto, Patrizio ;

Balducci, Elena ;

Balconi, Giovanna ;

Fiordaliso, Fabio ;

Merlo, Laura ;

Tuzzato, Giancarlo ;

Pappagallo, Giovanni L. ;

Frigato, Nicoletta ;

Zanocco, Albino ;

Forestieri, Concetta ;

Azzarello, Giuseppe ;

Mazzucco, Antonio ;

Valenti, Maria Teresa ;

Alborino, Flora ;

Noventa, Donatella ;

Vinante, Orazio ;

Pascotto, Piero ;

Sartore, Saverio ;

Dejana, Elisabetta ;

Latini, Roberto .

JOURNAL OF CARDIAC FAILURE, 2007, 13 (09) :701-708

[94] Immunoelectron microscopic characterization of human dermal lymphatic microvascular endothelial cells: Differential expression of CD31, CD34, and type IV collagen with lymphatic endothelial cells vs blood capillary endothelial cells in normal human skin, lymphangioma, and hemangioma in situ [J].

Sauter, B ;

Foedinger, D ;

Sterniczky, B ;

Wolff, K ;

Rappersberger, K .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1998, 46 (02) :165-176

[95] Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction [J].

Schaechinger, Volker ;

Erbs, Sandra ;

Elsaesser, Albrecht ;

Haberbosch, Werner ;

Hambrecht, Rainer ;

Hoelschermann, Hans ;

Yu, Jiangtao ;

Corti, Roberto ;

Mathey, Detlef G. ;

Hamm, Christian W. ;

Sueselbeck, Tim ;

Assmus, Birgit ;

Tonn, Torsten ;

Dimmeler, Stefanie ;

Zeiher, Andreas M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (12) :1210-1221

[96]

Schannwell CM, 2008, J KARDIOL, V15, P23

[97] Evidence that intracoronary-injected CD133+ peripheral blood progenitor cells home to the myocardium in chronic postinfarction heart failure [J].

Schots, Rik ;

De Keulenaer, Gilles ;

Schoors, Danny ;

Caveliers, Vicky ;

Dujardin, Martine ;

Verheye, Stefan ;

Van Camp, Guy ;

Franken, Philippe R. ;

Roland, Jan ;

Van Riet, Ivan ;

Everaert, Hendrik .

EXPERIMENTAL HEMATOLOGY, 2007, 35 (12) :1884-1890

[98] Percutaneous intracoronary cellular cardiomyoplasty for nonischemic cardiomyopathy: Clinical and histopathological results: The first-in-man ABCD (Autologous bone marrow cells in dilated cardiomyopathy) trial [J].

Seth, Sandeep ;

Narang, Rajiv ;

Bhargava, Balram ;

Ray, Ruma ;

Mohanty, Sujata ;

Gulati, Gurpreet ;

Kumar, Lalit ;

Md, K. Srinath Reddy ;

Venugopal, Panangipalli .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (11) :2350-2351

[99] The origin and in vivo significance of murine and human culture-expanded endothelial progenitor cells [J].

Sharpe, EE ;

Teleron, AA ;

Li, B ;

Price, J ;

Sands, MS ;

Alford, K ;

Young, PP .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (05) :1710-1721

[100] Evidence for circulating bone marrow-derived endothelial cells [J].

Shi, Q ;

Rafii, S ;

Wu, MHD ;

Wijelath, ES ;

Yu, C ;

Ishida, A ;

Fujita, Y ;

Kothari, S ;

Mohle, R ;

Sauvage, LR ;

Moore, MAS ;

Storb, RF ;

Hammond, WP .

BLOOD, 1998, 92 (02) :362-367

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