Rhodium-catalyzed asymmetric construction of quaternary carbon stereocenters: Ligand-dependent regiocontrol in the 1,4-addition to substituted maleimides

被引：179

作者：

Shintani, R ^{[1
]}

Duan, WL ^{[1
]}

Hayashi, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 17期

关键词：

D O I：

10.1021/ja061430d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to substituted maleimides has been described. The regioselectivity in this reaction is controlled by the choice of ligand (dienes or bisphosphines), and 1,4-adducts with a quaternary stereocenter can be obtained with high regio- and enantioselectivity by the use of (R)-H8-binap. Copyright © 2006 American Chemical Society.

引用

页码：5628 / 5629

页数：2

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