An easy access to (S)-pyrrolidinones and -pyrrolidines from chiral benzylic malonates

被引：10

作者：

Arzel, P ^{[1
]}

Freida, V ^{[1
]}

Weber, P ^{[1
]}

Fadel, A ^{[1
]}

机构：

[1] Univ Paris 11, Inst Chim Mol Orsay, CNRS, Lab Carbocycles, F-91405 Orsay, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(99)00425-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

From chiral benzylic malonic acid esters (R)-(+)-4, available with high enantiomeric excesses by enzymatic hydrolysis (PLE acetonic powder), enantiomerically enriched pyrrolidinones 1 and pyrrolidines 2 were prepared. This rapid and competitive method was developed via enol ether formation, and subsequent one-pot cyclisation, in good overall yield. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3877 / 3881

页数：5

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