Interferon-γ therapy reduces blood leukocyte levels in patients with atopic dermatitis:: Correlation with clinical improvement

被引:26
作者
Ellis, CN
Stevens, SR
Blok, BK
Taylor, RS
Cooper, KD
机构
[1] Case Western Reserve Univ, Univ Hosp Cleveland, Dept Dermatol, Cleveland, OH 44106 USA
[2] Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI 48109 USA
[3] Vet Affairs Med Ctr, Ann Arbor, MI 48109 USA
[4] Louis Stokes Vet Affairs Hosp, Cleveland, OH 44106 USA
关键词
atopic dermatitis; interferon-gamma; leukocytes; lymphocytes;
D O I
10.1006/clim.1999.4731
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Atopic dermatitis (AD) is a chronic inflammatory skin disease with abnonmalities of both cellular and humoral immunity. Subcutaneous recombinant human interferon-gamma (IFN-gamma) provides therapeutic benefit to AD patients. In contrast to expectations, IFN-gamma does not cause a decrease in the elevated levels of circulating IgE levels in AD patients, We sought to determine cellular targets of IFN-gamma treatment that might explain its clinical benefit. Therefore, we evaluated blood leukocyte subsets by multiparameter flow cytometry in AD patients receiving IFN-gamma (n = 10) or placebo (n = 11) therapy compared to untreated normal volunteers (n = 14). Treated patients demonstrated reductions in WBC, eosinophil, and lymphocyte counts. Compared to normals, there was a reduced CD4/CD8 ratio in AD patients among activated, large mononuclear cells that was partially corrected with IFN-gamma treatment. Clinical improvement correlated with reductions in WBC (r = 0.9, P = 0.0003), eosinophil (r = 0.7, P = 0.035) and lymphocyte (r = 0.8, P = 0.013) counts, and with normalization of the CD4/CD8 ratio among large lymphocytes (r = 0.9, P = 0.04). The data indicate two potential modes of actio:n for INF-gamma in AD. One mechanism represents normalization of selected immunologic abnormalities in AD; a second mechanism may be the modest reduction of circulating inflammatory cells. Adequacy of IFN-gamma therapy of AD may depend on bringing about these changes. (C) 1999 Academic Press.
引用
收藏
页码:49 / 55
页数:7
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