The cell stress machinery and retinal degeneration

被引：136

作者：

Athanasiou, Dimitra ^{[1
]}

Aguila, Monica ^{[1
]}

Bevilacqua, Dalila ^{[1
]}

Novoselov, Sergey S. ^{[1
]}

Parfitt, David A. ^{[1
]}

Cheetham, Michael E. ^{[1
]}

机构：

[1] UCL Inst Ophthalmol, London EC1V 9EL, England

来源：

FEBS LETTERS | 2013年 / 587卷 / 13期

基金：

英国惠康基金;

关键词：

Molecular chaperones; Cell stress; Neurodegeneration; Retinal degeneration photoreceptor; Rhodopsin ERAD; Autophagy; Retinitis pigmentosa; Glaucoma; Age-related macular degeneration; ENDOPLASMIC-RETICULUM STRESS; RETINITIS-PIGMENTOSA; ER STRESS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; DIABETIC-RETINOPATHY; MOLECULAR CHAPERONE; CHEMICAL CHAPERONE; MUTANT RHODOPSIN; QUALITY-CONTROL;

D O I：

10.1016/j.febslet.2013.05.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Retinal degenerations are a group of clinically and genetically heterogeneous disorders characterised by progressive loss of vision due to neurodegeneration. The retina is a highly specialised tissue with a unique architecture and maintaining homeostasis in all the different retinal cell types is crucial for healthy vision. The retina can be exposed to a variety of environmental insults and stress, including light-induced damage, oxidative stress and inherited mutations that can lead to protein misfolding. Within retinal cells there are different mechanisms to cope with disturbances in proteostasis, such as the heat shock response, the unfolded protein response and autophagy. In this review, we discuss the multiple responses of the retina to different types of stress involved in retinal degenerations, such as retinitis pigmentosa, age-related macular degeneration and glaucoma. Understanding the mechanisms that maintain and re-establish proteostasis in the retina is important for developing new therapeutic approaches to fight blindness. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2008 / 2017

页数：10

共 129 条

[1]

Expression of heat shock transcription factors and heat shock protein 72 in rat retina after intravitreal injection of low dose N-methyl-D-aspartate [J].