Adapting proteostasis for disease intervention

被引：1879

作者：

Balch, William E. ^{[3
,4
]}

Morimoto, Richard I. ^{[5
]}

Dillin, Andrew ^{[6
]}

Kelly, Jeffery W. ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA

[5] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Rice Inst Biomed Res, Evanston, IL 60208 USA

[6] Salk Inst Biol Studies, La Jolla, CA 92037 USA

来源：

SCIENCE | 2008年 / 319卷 / 5865期

关键词：

D O I：

10.1126/science.1141448

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small- molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/ or the location of protein( s) have the potential to ameliorate some of the most challenging diseases of our era.

引用

页码：916 / 919

页数：4

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