Localization of A:T and G:C basepairs in genomes of higher eukaryotes

被引:2
作者
Amano, N
Suzuki, M
机构
[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058566, Japan
[2] Univ Tsukuba, Doctoral Program Med Sci, Tsukuba, Ibaraki 3050006, Japan
来源
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2002年 / 78卷 / 05期
关键词
Arabidopsis thaliana; DNA replication; evolution; gene transcription; human genome;
D O I
10.2183/pjab.78.117
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
By using a visual method of presenting DNA sequences (Makino, S., Amano, N., and Suzuki, M., 1999, Proc. Japan Acad. 7511, 311-316), genomic sequences of various organisms have been analyzed, including of a draft sequence of human genome (International Human Genome Sequencing Consortium, 2001, Nature 409, 860-921). It is concluded that, with an increase in the number of basepairs in a genome, a tendency becomes clearer for clustering of A:T pairs and G:C pairs separately into regions of 0.5-5 K basepairs in length. It is likely that these regions have important functions for regulating transcription of the increasing number of genes coded and for organizing replication of the increasing length of genomic DNA.
引用
收藏
页码:117 / 122
页数:6
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