THE MINIMAL GENE COMPLEMENT OF MYCOPLASMA-GENITALIUM

被引：1980

作者：

FRASER, CM

GOCAYNE, JD

WHITE, O

ADAMS, MD

CLAYTON, RA

FLEISCHMANN, RD

BULT, CJ

KERLAVAGE, AR

SUTTON, G

KELLEY, JM

FRITCHMAN, JL

WEIDMAN, JF

SMALL, KV

SANDUSKY, M

FUHRMANN, J

NGUYEN, D

UTTERBACK, TR

SAUDEK, DM

PHILLIPS, CA

MERRICK, JM

TOMB, JF

DOUGHERTY, BA

BOTT, KF

HU, PC

LUCIER, TS

PETERSON, SN

SMITH, HO

HUTCHISON, CA

VENTER, JC

机构：

[1] SUNY BUFFALO, DEPT MICROBIOL, BUFFALO, NY 14214 USA

[2] JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD 21205 USA

[3] UNIV N CAROLINA, SCH MED, CHAPEL HILL, NC 27599 USA

来源：

SCIENCE | 1995年 / 270卷 / 5235期

关键词：

D O I：

10.1126/science.270.5235.397

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.

引用

收藏

页码：397 / 403

页数：7

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