MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators

被引：40

作者：

El Gazzar, Mohamed ^{[1
]}

McCall, Charles E. ^{[2
,3
]}

机构：

[1] E Tennessee Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA

[2] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Sect Mol Med, Winston Salem, NC 27103 USA

[3] Wake Forest Univ, Bowman Gray Sch Med, Translat Sci Inst, Winston Salem, NC 27103 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2012年 / 90卷 / 06期

关键词：

innate immunity; miRNAs; myeloid differentiation; transcription factors; TRANSCRIPTION FACTOR PU.1; SUPPRESSOR-CELLS; GENE-EXPRESSION; SELF-RENEWAL; C-MYC; REQUIREMENT; PROGENITOR; GATA-1; PROLIFERATION; INFLAMMATION;

D O I：

10.1038/icb.2011.74

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

MicroRNAs (miRNAs) are abundant small molecules of similar to 22 nucleotides that reprogram gene expression by targeting mRNA degradation and translation disruption. An emerging concept implicates miRNA coupling with transcription factors in myeloid-based development of dendritic cells, monocytes and granulocytes, as well as function as mature cells and contributors to host defense and inflammation. Here, we review this new and important interactive circuitry and how it contributes to reprogramming cell phenotypic responses associated with mature immune competency. Immunology and Cell Biology (2012) 90, 587-593; doi:10.1038/icb.2011.74; published online 13 September 2011

引用

页码：587 / 593

页数：7

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