Requirements for Th1-dependent immunity against infection with Leishmania major

被引：74

作者：

von Stebut, E

Udey, MC

机构：

[1] Johannes Gutenberg Univ Mainz, Dept Dermatol, D-55101 Mainz, Germany

[2] NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 12期

关键词：

Leishmania; dendritic cells; Th1; IL-12; macrophages;

D O I：

10.1016/j.micinf.2004.05.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protective immunity against cutaneous leishmaniasis is dependent on the induction of Thl/Tcl immune responses resulting in efficient parasite elimination. In this review, the mechanisms leading to protection are discussed with special focus on the role of Leishmania major-infected dendritic cells (DC) in induction of Thl-dependent immunity. Murine strain-dependent differences between DC derived from Leishmania-susceptible as compared to resistant mice are highlighted. (c) 2004 Elsevier SAS. All rights reserved.

引用

收藏

页码：1102 / 1109

页数：8

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