Cutting edge:: Early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection

被引:90
作者
Artis, D
Johnson, LM
Joyce, K
Saris, C
Villarino, A
Hunter, CA
Scott, P
机构
[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
[2] Amgen Inc, Dept Inflammat Res, Thousand Oaks, CA 91320 USA
关键词
D O I
10.4049/jimmunol.172.8.4672
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
There are conflicting reports on the requirements for the IL-27-WSX-1 pathway in the development of Th type 1 responses and resistance to intracellular pathogens, although early IFN-gamma production and resistance to Leishmania major are impaired. in the absence of WSX-1 signaling, WSX-1(-/-) mice generate robust IFN-gamma responses and control infection with other intracellular protozoan pathogens. In this report, we resolve these conflicting observations and demonstrate that, in the absence of IL-4, WSX-1 is not required for early IFN-gamma production and control of L. major. Thus, the requirement for WSX-1 signaling in Th type I cell differentiation,is restricted to conditions in which IL-4 is produced.
引用
收藏
页码:4672 / 4675
页数:4
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