Pre-mRNA Processing Reaches Back to Transcription and Ahead to Translation

被引：675

作者：

Moore, Melissa J. ^{[1
,2
]}

Proudfoot, Nick J. ^{[3
]}

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

[3] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

CELL | 2009年 / 136卷 / 04期

基金：

英国惠康基金;

关键词：

EXON-JUNCTION COMPLEX; NONSENSE-MEDIATED DECAY; POLYMERASE-II TRANSCRIPTS; C-TERMINAL DOMAIN; GENE-EXPRESSION; SR PROTEINS; IN-VIVO; CYTOPLASMIC LOCALIZATION; CAENORHABDITIS-ELEGANS; UPF1; PHOSPHORYLATION;

D O I：

10.1016/j.cell.2009.02.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 50 cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.

引用

页码：688 / 700

页数：13

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