Facile Synthesis of Steroidal Primary Amides via Palladium-Catalyzed Aminocarbonylation of Steroidal Alkenyl Halides

被引：18

作者：

Balogh, Janos ^{[1
]}

Maho, Sandor ^{[2
]}

Hada, Viktor ^{[2
]}

Kollar, Laszlo ^{[3
]}

Skoda-Foeldes, Rita ^{[1
]}

机构：

[1] Univ Pannonia, Inst Chem, Dept Organ Chem, H-8201 Veszprem, Hungary

[2] Chem Works Gedeon Richter Ltd, H-1475 Budapest 10, Hungary

[3] Univ Pecs, Dept Inorgan Chem, H-7624 Pecs, Hungary

来源：

SYNTHESIS-STUTTGART | 2008年 / 19期

基金：

美国国家科学基金会;

关键词：

primary amides; carbonylations; steroids; palladium; homogeneous catalysis;

D O I：

10.1055/s-2008-1067265

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of primary amides from alkenyl iodides in one carbonylation Step using ammonium carbamate as ammonia synthon is reported. The products were obtained in good yields under mild reaction conditions using CO (1-6 bar). Steroidal substrates with various moieties (e.g., 6-OH group, lactams. or aromatic A-ring) Could be converted selectively into the products.

引用

页码：3040 / 3042

页数：3

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