Stereospecific formal total synthesis of ecteinascidin 743

被引：95

作者：

Zheng, SP ^{[1
]}

Chan, C ^{[1
]}

Furuuchi, T ^{[1
]}

Wright, BJD ^{[1
]}

Zhou, B ^{[1
]}

Guo, J ^{[1
]}

Danishefsky, S ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 11期

关键词：

antitumor agents; asymmetric synthesis; natural products; Pictet-Spengler reaction; total synthesis;

D O I：

10.1002/anie.200503983

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A new strategy was designed for the construction of the pentacyclic ring system of ecteinascidin 743. Key features include highly concise routes to the enantiopure, configurationally matched subunit 1, a novel vinylogous Pictet-Spengler cyclization to 2, and a stereospecific epoxidation and regioselective reduction sequence of the C3-C4 enamide to secure 3. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：1754 / 1759

页数：6

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