Cancer Epigenetics: From Mechanism to Therapy

被引：2381

作者：

Dawson, Mark A. ^{[1
,2
,3
,4
]}

Kouzarides, Tony ^{[1
,2
]}

机构：

[1] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QN, England

[3] Univ Cambridge, Cambridge Inst Med Res, Dept Haematol, Cambridge CB2 0XY, England

[4] Univ Cambridge, Addenbrookes Hosp, Cambridge CB2 0XY, England

来源：

CELL | 2012年 / 150卷 / 01期

关键词：

HISTONE DEACETYLASE INHIBITORS; IDENTIFIES FREQUENT MUTATION; METHYLTRANSFERASE GENE EZH2; CHROMATIN REMODELING GENES; ACUTE MYELOID-LEUKEMIA; SOMATIC MUTATIONS; DNA METHYLATION; INACTIVATING MUTATIONS; MOLECULAR-MECHANISMS; GENOME;

D O I：

10.1016/j.cell.2012.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The epigenetic regulation of DNA-templated processes has been intensely studied over the last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA-mediated targeting regulate many biological processes that are fundamental to the genesis of cancer. Here, we present the basic principles behind these epigenetic pathways and highlight the evidence suggesting that their misregulation can culminate in cancer. This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it is time to embrace the central role of epigenetics in cancer.

引用

页码：12 / 27

页数：16

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