Membrane fusion:: SNAREs and regulation

被引：163

作者：

Malsam, J. ^{[1
]}

Kreye, S. ^{[1
]}

Soellner, T. H. ^{[1
]}

机构：

[1] Heidelberg Univ, Biochem Ctr, D-69120 Heidelberg, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 18期

基金：

美国国家卫生研究院;

关键词：

exocytosis; fusion; vesicle; tether; synaptotagmin; SM protein; Munc13; complexin;

D O I：

10.1007/s00018-008-8352-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines the plasticity of regulated exocytosis.

引用

页码：2814 / 2832

页数：19

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