PET studies of 18F-memantine in healthy volunteers

被引：39

作者：

Ametamey, SM ^{[1
]}

Bruehlmeier, M

Kneifel, S

Kokic, M

Honer, M

Arigoni, M

Buck, A

Burger, C

Samnick, S

Quack, G

Schubiger, PA

机构：

[1] ETH Zurich, PSI, Ctr Radiopharmaceut Sci, CH-5232 Villigen, Switzerland

[2] USZ, CH-5232 Villigen, Switzerland

[3] Univ Zurich Hosp, Div Nucl Med, Zurich, Switzerland

[4] Merz & Co GmbH Co, D-60318 Frankfurt, Germany

[5] Univ Saarland, Div Nucl Med, D-66421 Homburg, Germany

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2002年 / 29卷 / 02期

关键词：

F-18-memanine; NMDA receptor; PET;

D O I：

10.1016/S0969-8051(01)00293-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Previous studies in mice and PET investigations in a Rhesus monkey showed that the regional uptake of F-18-memantine could be blocked by pharmacological doses of memantine and (+)-MK-801. In the present study, the binding characteristics of F-18-memantine was examined in five healthy volunteers. In humans. F-18-memantine was homogeneously distributed in gray matter i.e. cortex and basal ganglia regions, as well as the cerebellum. No radioactive metabolites were detected in plasma during the time-frame of the PET studies. The uptake of F-18-memantine in receptor-rich re-ions such as striatum and frontal cortex could be well described by a 1-tissue compartment model. The DV" values of all gray matter regions were similar and ranged from 15 to 20 ml/ml. The white matter showed lower DV" values of 15 +/- 1.4 ml/ml. These results suggest that F-18-memantine distribution in human brain does not reflect the regional NMDA receptor concentration, and therefore, this radioligand is not suitable for the PET imaging of the NMDA receptors. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：227 / 231

页数：5

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