PET STUDIES OF [F-18] METHYL-MK-801, A POTENTIAL NMDA RECEPTOR COMPLEX RADIOLIGAND

被引：38

作者：

BLIN, J

DENIS, A

YAMAGUCHI, T

CROUZEL, C

MACKENZIE, ET

BARON, JC

机构：

[1] INSERM,U320,BP5027,F-14021 CAEN,FRANCE

[2] CEA,SERV HOSP FEDERIC JOLIOT,DEPT BIOL,ORSAY,FRANCE

[3] LAB ETUD & RECH SCI SYNTHELABO,BAGNEUX,FRANCE

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

POSITRON EMISSION TOMOGRAPHY; MK-801; NMDA RECEPTOR; PHENCYCLIDINE;

D O I：

10.1016/0304-3940(91)90680-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using positron emission tomography (PET), the potential of F-18-labelled fluoro-methyl-MK-801 ([F-18]FMM) as a radioligand for in vivo studies of the NMDA receptor complex was investigated in baboons. In baseline conditions, there was a slight differential retention of [F-18]FMM in cerebral cortex and striatum relative to cerebellum, compatible with specific binding. However, neither pretreatment with pharmacological doses of MK-801 or phencyclidine, nor severe, transient brain hypoxia, were able to clearly alter [18]FMM brain regional kinetics, indicating limited usefulness of this radioligand for in vivo PET investigations of the NMDA receptor.

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页码：183 / 186

页数：4

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