The leukocyte immunoglobulin-like receptors (LIRs): a new family of immune regulators

被引:22
作者
Fanger, NA [1 ]
Borges, L [1 ]
Cosman, D [1 ]
机构
[1] Immunex Res & Dev Corp, Seattle, WA 98101 USA
关键词
monocyte; Fc receptor; MHC class I; cytomegalovirus; UL18;
D O I
10.1002/jlb.66.2.231
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Identification of a counterstructure for the human cytomegalovirus-encoded major histocompatibility complex class I-related gene product, UL18, has led to the discovery of a novel family of immunoreceptors, termed leukocyte immunoglobulin-like receptors (LIRs). The LIRs are differentially expressed in cells of the dendritic cell, monocytic and lymphocytic lineages, and appear to mediate diverse roles in immune regulation, This review summarizes the expression, distribution, and signaling capacities of the LIRs and discusses possible roles of the LIRs in both inhibition and activation of the cellular responses.
引用
收藏
页码:231 / 236
页数:6
相关论文
共 66 条
[51]   Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin [J].
Olweus, J ;
BitMansour, A ;
Warnke, R ;
Thompson, PA ;
Carballido, J ;
Picker, LJ ;
LundJohansen, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) :12551-12556
[52]  
PHILLIPS NE, 1983, J IMMUNOL, V130, P602
[53]   The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells [J].
Reyburn, HT ;
Mandelboim, O ;
ValesGomez, M ;
Davis, DM ;
Pazmany, L ;
Strominger, JL .
NATURE, 1997, 386 (6624) :514-517
[54]  
Rojo S, 1997, J IMMUNOL, V158, P9
[55]   Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways [J].
Samaridis, J ;
Colonna, M .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (03) :660-665
[56]   The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP? [J].
Scharenberg, AM ;
Kinet, JP .
CELL, 1996, 87 (06) :961-964
[57]  
SCHOLL PR, 1992, J IMMUNOL, V149, P1751
[58]   One step ahead of the game: Viral immunomodulatory molecules [J].
Spriggs, MK .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :101-130
[59]   Chromosomal localization of the human natural killer cell class I receptor family genes to 19q13.4 by fluorescence in situ hybridization [J].
Suto, Y ;
Maenaka, K ;
Yabe, T ;
Hirai, M ;
Tokunaga, K ;
Tadokoro, K ;
Juji, T .
GENOMICS, 1996, 35 (01) :270-272
[60]  
Vely F, 1997, J IMMUNOL, V159, P2075