Increased midbrain gray matter in Tourette's syndrome

被引：43

作者：

Garraux, G

Goldfine, A

Bohlhalter, S

Lerner, A

Hanakawa, T

Hallett, M

机构：

[1] NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA

[2] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

[3] Univ Liege, Dept Neurol, B-4000 Liege, Belgium

来源：

ANNALS OF NEUROLOGY | 2006年 / 59卷 / 02期

关键词：

D O I：

10.1002/ana.20765

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To investigate cerebral structure in Tourette's syndrome (TS). Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls. Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508514) according to which midbrain disturbances play an important pathogenic role in TS.

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页码：381 / 385

页数：5

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