Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

被引：210

作者：

Pende, D

Castriconi, R

Romagnani, P

Spaggiari, GM

Marcenaro, S

Dondero, A

Lazzeri, E

Lasagni, L

Martini, S

Rivera, P

Capobianco, A

Moretta, L

Moretta, A

Bottino, C

机构：

[1] Ist Nazl Ric Canc, I-16132 Genoa, Italy

[2] Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy

[3] Ist Giannina Gaslini, Genoa, Italy

[4] Univ Florence, Ctr Res Transfer & High Educ De Nono Therapies, Florence, Italy

[5] Univ Genoa, Ctr Eccellenza Ric Biomed, Genoa, Italy

[6] Univ Genoa, Dipartimento Oncol Biol & Genet, I-16126 Genoa, Italy

来源：

BLOOD | 2006年 / 107卷 / 05期

关键词：

D O I：

10.1182/blood-2005-07-2696

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this study, we demonstrate the involvement of DNAM-1-triggering receptor and its ligands, poliovirus receptor (PVR) and Nectin-2, in natural killer (NK) cell-mediated lysis of dendritic cells (DCs). The surface expression of both ligands was up-regulated in DCs as compared to monocytes. It reached maximal densities after DC maturation induced by different stimuli including lipopolysaccharide (LPS), poly I:C, flagellin, and CD40L. Both immunohistochemical analysis and confocal microscopy revealed expression of DNAM-1 ligands by DCs in lymph nodes in which they were localized in the parafollicular T-cell region and surrounded the high endothelial venules. Remarkably, in cytolytic assays, DNAM-1 cooperated with NKp30 in the NK-mediated killing of both immature and mature DCs and the degree of contribution of DNAM-1 appeared to correlate with the surface densities of its specific ligands PVR and Nectin-2.

引用

页码：2030 / 2036

页数：7

共 42 条

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