Paramutation: a trans-homolog interaction affecting heritable gene regulation

被引：44

作者：

Hollick, Jay B. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2012年 / 15卷 / 05期

基金：

美国国家科学基金会;

关键词：

DEPENDENT RNA-POLYMERASE; MAIZE P1 GENE; ZEA-MAYS; TRANSPOSABLE ELEMENTS; ARABIDOPSIS-THALIANA; EPIGENETIC STATES; HYBRID VIGOR; B1; LOCUS; R-LOCUS; EXPRESSION;

D O I：

10.1016/j.pbi.2012.09.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Paramutation describes both the process and results of trans-sensing between chromosomes that causes specific heritable changes in gene regulation. RNA molecules are implicated in mediating similar events in maize, mouse, and Drosophila. Changes in both small RNA profiles and cytosine methylation patterns in Arabidopsis hybrids represent a potential molecular equivalent to the interactions responsible for paramutations. Despite a seemingly unifying feature of RNA-directed changes, both recent and historical works show that paramutations in maize require plant-specific proteins and lack expected hallmarks of a trans-effect mediated solely by RNAs. Recent examples of nearby transposons affecting RNA polymerase II functions lead to an opinion that paramutations represent an emergent property of the transcriptional dynamics ongoing in plant genomes between repetitious features and nearby genes.

引用

页码：536 / 543

页数：8

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