Molecular mechanism of intestinal permeability: interaction at tight junctions

被引：64

作者：

Hossain, Zakir ^{[1
]}

Hirata, Takashi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Biosci, Kyoto 6068502, Japan

来源：

MOLECULAR BIOSYSTEMS | 2008年 / 4卷 / 12期

关键词：

D O I：

10.1039/b800402a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intestinal barrier plays a critical role in humans in the transport of nutrients and macromolecules. At the same time, it has to provide an effective barrier to harmful macromolecules and microorganisms. The tight junction (TJ) is an essential component of this barrier. The junctional complexes of the plasma membrane are not simply epithelial barriers in paracellular transport or barriers preventing diffusion in the plasma membrane, but also contain proteins involved in signal transduction and the maintenance of the physiological epithelial cell state. Occludin, claudin, junctional adhesion molecules, and the coxsackie virus and adenovirus receptor are the major components of TJs. This article highlights the structure and function of TJs as well as the molecular interactions occurring during permeation through TJs.

引用

页码：1181 / 1185

页数：5

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