Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death

被引：78

作者：

Subramaniam, S ^{[1
]}

Unsicker, K ^{[1
]}

机构：

[1] Heidelberg Univ, Neuroanat & Interdisciplinary Ctr Neurosci, D-69120 Heidelberg, Germany

来源：

NEUROSCIENCE | 2006年 / 138卷 / 04期

关键词：

ERK; autophagy; caspase; calpains; ischemia; calcium;

D O I：

10.1016/j.neuroscience.2005.12.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular signal-regulated kinase (ERK) is a versatile protein kinase, which has been implicated in signaling numerous biological functions ranging from embryonic development to memory formation. Recent reports, including ours, indicate that ERK plays a central role in promoting neuronal degeneration in various neuronal systems including neurodegenerative diseases. Mechanisms involved in ERK-induced neuronal degeneration are beginning to emerge. In this review, we summarize evidence suggesting ERK to be a predominant inducer of a non-apoptotic mode of neuronal death. Further, we discuss the mechanisms and the putative molecular inter-players associated with ERK-mediated neuronal death. (C) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1055 / 1065

页数：11

共 169 条

[1] Modulation of the Ras/Raf/MEK/ERK pathway by Ca2+, and calmodulin [J].

Agell, N ;

Bachs, O ;

Rocamora, N ;

Villalonga, P .

CELLULAR SIGNALLING, 2002, 14 (08) :649-654

[2] Oxidative stress activates extracellular signal-regulated kinases through Src and ras in cultured cardiac myocytes of neonatal rats [J].

Aikawa, R ;

Komuro, I ;

Yamazaki, T ;

Zou, YZ ;

Kudoh, S ;

Tanaka, M ;

Shiojima, I ;

Hiroi, Y ;

Yazaki, Y .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (07) :1813-1821

[3] MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia [J].

Alessandrini, A ;

Namura, S ;

Moskowitz, MA ;

Bonventre, JV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12866-12869

[4] Cl-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) [J].

Allen, LF ;

Sebolt-Leopold, J ;

Meyer, MB .

SEMINARS IN ONCOLOGY, 2003, 30 (05) :105-116

[5] Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions [J].

Annunziato, L ;

Amoroso, S ;

Pannaccione, A ;

Cataldi, M ;

Pignataro, G ;

D'Alessio, A ;

Sirabella, R ;

Secondo, A ;

Sibaud, L ;

Di Renzo, GF .

TOXICOLOGY LETTERS, 2003, 139 (2-3) :125-133

[6] Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells [J].

Arany, I ;

Megyesi, JK ;

Kaneto, H ;

Price, PM ;

Safirstein, RL .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (03) :F543-F549

[7] Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease [J].

Barzilai, A ;

Melamed, E .

TRENDS IN MOLECULAR MEDICINE, 2003, 9 (03) :126-132

[8] Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms [J].

Belmokhtar, CA ;

Hillion, J ;

Ségal-Bendirdjian, E .

ONCOGENE, 2001, 20 (26) :3354-3362

[9] Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: Role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death [J].

Bhat, NR ;

Zhang, PS .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (01) :112-119

[10] Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap [J].

Botella, JA ;

Kretzschmar, D ;

Kiermayer, C ;

Feldmann, P ;

Hughes, DA ;

Schneuwly, S .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (01) :241-250

← 1 2 3 4 5 6 7 8 9 10 →