Extracellular signal-regulated kinase as an inducer of non-apoptotic neuronal death

被引：78

作者：

Subramaniam, S ^{[1
]}

Unsicker, K ^{[1
]}

机构：

[1] Heidelberg Univ, Neuroanat & Interdisciplinary Ctr Neurosci, D-69120 Heidelberg, Germany

来源：

NEUROSCIENCE | 2006年 / 138卷 / 04期

关键词：

ERK; autophagy; caspase; calpains; ischemia; calcium;

D O I：

10.1016/j.neuroscience.2005.12.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extracellular signal-regulated kinase (ERK) is a versatile protein kinase, which has been implicated in signaling numerous biological functions ranging from embryonic development to memory formation. Recent reports, including ours, indicate that ERK plays a central role in promoting neuronal degeneration in various neuronal systems including neurodegenerative diseases. Mechanisms involved in ERK-induced neuronal degeneration are beginning to emerge. In this review, we summarize evidence suggesting ERK to be a predominant inducer of a non-apoptotic mode of neuronal death. Further, we discuss the mechanisms and the putative molecular inter-players associated with ERK-mediated neuronal death. (C) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：1055 / 1065

页数：11

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