Curcumin is a potent DNA hypomethylation agent

被引：272

作者：

Liu, Zhongfa ^{[1
,2
]}

Xie, Zhiliang ^{[1
,2
]}

Jones, William ^{[1
]}

Pavlovicz, Ryan E. ^{[6
]}

Liu, Shujun ^{[2
,3
]}

Yu, Jianhua ^{[2
,3
]}

Li, Pui-kai ^{[7
]}

Lin, Jiayuh ^{[8
]}

Fuchs, Jame R. ^{[7
]}

Marcucci, Guido ^{[2
,3
,4
,5
]}

Li, Chenglong ^{[7
]}

Chan, Kenneth K. ^{[1
,2
]}

机构：

[1] Ohio State Univ, Coll Pharm, Div Pharmaceut, Columbus, OH 43210 USA

[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[3] Ohio State Univ, Div Hematol Oncol, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA

[5] Ohio State Univ, Dept Mol Virol, Columbus, OH 43210 USA

[6] Ohio State Univ, Dept Biomed Engn, Columbus, OH 43210 USA

[7] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA

[8] Ohio State Univ, Nationwide Childrens Hosp, Res Inst, Ctr Childhood Canc, Columbus, OH 43210 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Curcumin; DNA hypomethylation agent; CANCER-CELL LINES; METHYLTRANSFERASE INHIBITORS; DECITABINE; ANTITUMOR; LEUKEMIA; TRIAL; GENES;

D O I：

10.1016/j.bmcl.2008.12.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC50 of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 mu M. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line. Published by Elsevier Ltd.

引用

页码：706 / 709

页数：4

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