Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

被引：139

作者：

El Karim, Ikhlas A. ^{[1
]}

Linden, Gerard J. ^{[1
]}

Orr, David F. ^{[2
]}

Lundy, Fionnuala T. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Med & Dent, Oral Sci Res Ctr, Belfast BT12 6BP, Antrim, North Ireland

[2] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 200卷 / 1-2期

关键词：

Neuropeptides; Oral pathogens; Antimicrobial activity; Radial diffusion assay;

D O I：

10.1016/j.jneuroim.2008.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：11 / 16

页数：6