Uric acid in Parkinson's disease

被引：95

作者：

Schlesinger, Ilana ^{[1
]}

Schlesinger, Naomi ^{[2
]}

机构：

[1] Movement Disorders Clin, Dept Neurol, IL-31096 Haifa, Israel

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Div Rheumatol, New Brunswick, NJ USA

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 12期

关键词：

uric acid; urate; Parkinson's disease; neuroprotection;

D O I：

10.1002/mds.22139

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies have provided evidence that uric acid may play a role in the development and progression of Parkinson's disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. Higher levels of serum urate (SU) may have a neuroprotective effect. High SU levels reduced the risk of developing PD and con-elated with slower PD progression. Among PD patients SU levels were lower as compared with controls. The manipulation of SU levels holds promise in the treatment of PD. It is possible that a high purine diet in patients with PD may slow progression of the disease. Milk and meat consumption as well as exercise modify the risk of developing PD possibly through their influence on SU levels. In this article, we review the association between PD and SU levels and its implication on the management of PD. (C) 2008 Movement Disorder Society.

引用

页码：1653 / 1657

页数：5

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